Current Issue : October - December Volume : 2016 Issue Number : 4 Articles : 6 Articles
The principle goal of the study was to blend third era of citrus extract dendrimer by connecting polyethylene glycol\nfor diminishing systemic poisonous quality which is non-particular and to give delayed release of the drug called cefixime by\nexpanding the dissemination time of the drug. Safe and specific focusing of drug into the cells without damage of normal blood\ncells was finished by entrapment of cefixime drug into the PEGylated dendrimer. The drug loaded formulations were assessed\nfor their in-vitro release studies and physicochemical properties. This study demonstrated huge delayed release of cefixime\ncontrasted and non-PEGylated dendrimeric framework....
This work endeavors at increasing dissolution profile of BCS-II class anti-depressant drug mirtazapine (MIR) by formulating it into self emulsifying drug delivery system. The work involved fabrication of thirty-two formulations using different oils (sesame oil, peanut oil, olive oil and eucalyptus oil), surfactants and co-surfactants (PEG 200, 300 and 400, Span 20 and 80). The formulations were characterized suitably and underwent tests for organoleptic properties, thermodynamic stability, physical nature, physicochemical properties, drug content, dissolution characteristics and accelerated stability studies. Two microemulsion formulations (A6 and A8) were found to be optimized. The optimum formulation (A6) showed cloud point 83±1°C, globule size 266±1.71 nm, viscosity 96.95±1.16 cps, polydispersity index 0.058±0.03 and zeta potential -29.3±2.7 mV. The formulations demonstrated higher dissolution profile (78.22% and 64.41%) than the commercially available tablet formulation (9.47%). Formulation A6 was found to be highly stable and demonstrated no significant changes in accelerated stability studies, which concluded that sesame oil and span 20 are good candidates in preparation of microemulsion. In conclusion, the results suggested that the SEDDS of MIR may be a better dosage form compared to conventional formulations; thereby resulting in enhanced solubility, improved dissolution profile and enhanced patient compliance....
The purpose of this study was to formulate and evaluate self pore forming osmotically controlled drug delivery system of urapidil. Urapidil is antihypertensive agent belonging to BCS class II with relatively short elimination half life 4.7 hr. Main objective to formulate this system was to achieve zero order release for urapidil. The present study was also aimed to develop a system that would reduce the frequency of dosing and thus increases patient compliance. Cellulose acetate was used as semipermeable membrane. Potassium chloride was used as pore forming agent. PEG4000 was used as plasticizer. Mannitol, sucrose, sodium chloride used as osmotic agents. This system was developed in two stages; (a) formulation of core tablets and (b) coating of core tablet. Core tablets were evaluated for dimension, weight variation, hardness, drug content, disintegration, invitro release, while coated tablets were evaluated for appearance, weight variation, thickness, hardness, in-vitro release study....
The objective of present study was to formulate and evaluate gastro retentive extended release floating tablets of tramadol hydrochloride by direct compression technique. Tramadol hydrochloride is a non-steroidal anti-inflammatory drug used for osteoarthritis and for acute to chronic pain. Combination of hydrophilic polymers like hydroxyl propyl methyl cellulose (HPMCK4M, HPMC K15M and HPMC K100M) and polyethylene oxide (POLYOX WSR 303) are used as matrix retarding polymers for the preparation of gastro retentive extended release floating tablets. DSC and FTIR study indicated that there was no chemical interaction between drug and excipients. By varying the ratios of drug and polymer the formula was optimized for preparation of floating tablets. Pre and post compression parameters of all the formulations were within specified limits. Combination of HPMC K100M and POLYOX WSR 303 has shown better floating lag time and in-vitro release profiles. Among all formulations F14 with 20% HPMC K100M and 25% of POLYOX WSR 303 has shown in-vitro profiles upto 24 hrs with 98.63% drug release. Formulation F14 with 60:20 of sodium bicarbonate and citric acid shown floating lag time below 10 sec. Optimized formulation follows the first order release kinetics and dissolution data was analysed by korsmeyer-peppas model and it showed non fickian (anomalous) i.e. both swelling and diffusion release mechanism. Accelerated stability studies for 3 months indicated that tramadol hydrochloride was stable in floating tablets. Results of the present study indicated the suitability of hydrophilic polymers in the preparation of gastro retentive extended release floating tablets of tramadol hydrochloride....
Discoveries in the field of nanotechnology are triggering a revolution in medicine by providing a profusion of potential and actual applications of nanosized objects in the diagnosis and treatment of several diseases like, cancer and gene diseases. In this review, gold nanoparticles stood out as suitable platforms for the development of efficient delivery and release systems. Gold nanoparticles are biocompatible and can be easily synthesized and functionalized. The capability of tuning their size and geometry allows manipulating their optical and physical properties. Gold nanocages represent a novel class of nanostructures, well-suited for biomedical applications. The key feature of gold nanostructure is their attractive optical property i.e. the scattering and absorption of light at resonant wavelengths due to excitation of Plasmon oscillation. This phenomenon is called as Localized Surface Plasmon Resonance and is the source of ruby red color of conventional gold colloids. This novel class of hollow nanostructures is expected to find use as a contrast agent for optical imaging and as a therapeutic agent for photothermal treatment. This review will put down a special emphasis on the uniqueness of inorganic nanoparticles especially gold nanoparticles as a drug delivery vehicle and will present a wide spread scenario of gold nanoparticles that has been used for treatment of life threatening diseases....
Xanthan gum is modified to its carboxymethyl derivative which in turn can be used as sustained release delivery carrier as rate controlling polymer. The modified gum shows improved physical properties like good aqueous solubility, acceptable solution viscosity and clarity compared to the unmodified one. The reaction was carried out by using mono-chloroacetic acid and sodium hydroxide. Carboxymethylation was confirmed by fourier-transformed infra-red spectra. Metronidazole loaded polyelectrolyte complex was prepared by using carboxymethyl xanthan and chitosan. The resulting product was characterized by FTIR spectroscopy study. Polyelectrolyte complex was optimized with respect to concentration of carboxymethyl xanthan and chitosan....
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